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KMID : 0043320080310020188
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Archives of Pharmacal Research
2008 Volume.31 No. 2 p.188 ~ p.194
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The Effect of Lead on Calcium Release Activated Calcium Influk in Primary Cultures of Human Osteoblast-like Cells
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Jang Hye-Ock
Kwon Woo-Cheol
Kim Jeong-Kuk
Kim Dong-Ho
Jeon You-Jin
Kim Won-Il
Jung In-Kyo
Shin Sang-Hun
Chung Jin
Bae Moon-Kyung
Yun Il
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Abstract
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To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). Pb2+ inhibited the immediate CRACI dose-dependent manner. Influx of Pb2+ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of Pb2+ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of Ca2+ upon Ca2+ readdition, is partially inhibited by Pb2+ and (2) the influx of Pb2+ was enhanced after CRACI had been induced.
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KEYWORD
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Lead, Calcium influx, Osteoblast-like cells, Fluorescence probe technique
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